ABSTRACT
BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host.
Subject(s)
Humans , Trypanosoma cruzi/pathogenicity , /therapeutic use , Chemokines , Heart DiseasesABSTRACT
Avaliar a associação entre medidas antropométricas, de composição corporal, bioquímicas e de consumo alimentar em indivíduos com excesso de peso. Métodos: Estudodo tipo transversal, com amostra de conveniência composta por 31 indivíduos, com idade entre 19 e 59 anos. Foram realizadas avaliações antropométricas, bioquímicas e análise da composição da dieta. Após, foi calculado o índice de qualidade da dieta (IQD). Na análise estatística, o teste deShapiro-Wilk verificou a distribuição das variáveis, Wilcoxon-Mann- Whitney-U as diferenças entre as variáveis e correlação de Spearman/Pearson rastreou a associação entre os valores. Foi adotado um p com 5% de probabilidade.Resultados: A análise da composição da dieta permitiu observar uma média de consumo acima das Dietary Reference Intakes para carboidrato (323,31±33,11g), proteína (80,15±29,84g), lipídeo(77,42±31,87g) e sódio (2896,99±1119,05mg). Os valores para o IQD variaram entre 2 e 12 pontos, apresentando valor médio de 6,5±2,2. Foram encontradas correlações entre IQD e prega cutânea suprailíaca, colesterol total, e LDL-c (mg/dL), dentre outras. Conclusão:A amostra estudada apresentou um perfil de ingestão alimentar composto por alimentos ricos em carboidratos, lipídeos e sódio. A elevada média da pontuação do IQD (dieta pobre) refletea importância de medidas de intervenção visando à melhoria do padrão alimentar desses indivíduos...
To evaluate the association between the anthropometric and biochemical measures, body composition and food intake in overweight individuals.Methods: Cross- sectional study with a convenience sample of 31 individuals, aged between 19 and 59 years. Anthropometric and biochemical variables were assessed and diet composition was analyzed. The diet quality index (DQI) was then calculated. In the statistical analysis, theShapiro-Wilk test checked the distribution of variables, the Wilcoxon-Mann-Whitney-U checked the differences between them and Spearman/Pearson correlation tracked the association between the values. It was adopted p with 5% of probability.Results: The diet composition analysis showed an average intake above the Dietary Reference Intakes forcarbohydrate (323.31±33.11g), protein (80.15±29.84g), lipid (77.42±31.87g) and sodium(2,896.99±1,119.05mg). The DQI values varied between 2 and 12 points, with mean value of 6.5 ± 2.2. Correlations were found between DQI and the suprailiac skinfold, total cholesterol, LDL-cholesterol (mg/dL), among others. Conclusion: The sample showed a food intake profile comprising food rich in carbohydrates, lipids and sodium. The high average score of DQI (poor diet) reflects the importance of intervention measures aiming to improve the food pattern of these individuals...
Evaluar la asociación de medidas antropométricas,composición corporal, bioquímicas y consumo alimentarioen individuos con exceso de peso.Métodos: Estudio del tipotrasversal, con muestra de conveniencia constituida de 31 individuos con edad entre los 19 y 59 años. Fueron realizadas evaluaciones antropométricas, bioquímicas y el análisis de la composición de la dieta. Después, fue calculado el índice de calidad de dieta (ICD). En el análisis estadístico, la prueba de Shapiro-Wilk verificó la distribución de las variables, Wilcoxon-Mann-Whitney-U las diferencias entre las variables y la correlación de Spearman/Pearson rastreó la asociación entre los valores. Fue adoptado un p con el 5% de probabilidad. Resultados: El análisisde la composición de la dieta permitió observar una media de consumo por encima de las Dietary Reference Intakes para carboidrato (323,31±33,11g), proteína (80,15±29,84g), lipidio(77,42±31,87g) y sodio (2896,99±1119,05mg). Los valores para el IQD variaron entre 2 y 12 puntos, presentando valor medio de6,5±2,2. Fueron encontradas correlaciones entre el IQD y pliegacutánea suprailiaca, colesterol total, y LDL-c (mg/dL), entre otras.Conclusión: La muestra estudiada presentó un perfil de ingestaalimentaria constituido por alimentos ricos en carbohidratos, lípidos y sodio. La elevada media de la puntuación del IQD (dieta pobre) refleja la importancia de medidas de intervención con elobjetivo de mejorar el patrón alimentario de esos individuos...